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Proteus Structure Prediction Server
Comprehensive Secondary Structure Predictions
 
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  Welcome to Proteus


Proteus is a high-performing integrated web server and a stand-alone application three high-performing de novo structure prediction methods (PSIPRED, JNET and TRANSSEC [a locally developed predictor]), a jury-of-experts consensus tool and a robust PDB-based structure alignment process to generate all of its secondary structure predictions. For water-soluble protein Proteus is able to achieve a very high level of accuracy (Q3=88%, SOV=90%). In the rare situation (20-30%) where a query protein shows no similarity whatsoever to any known structure, PROTEUS is still able to achieve a Q3 score of 79%. Proteus is not restricted to generating accurate secondary structures for water-soluble proteins, as it appears to perform well for integral membrane proteins (both helix-containing proteins and beta-sheet containing porins) that have remote homologues or a portion of a homologue in the PDB. The 2D-to-3D structure mapping is accomplished with a continually updated PDB secondary structure database available for download (see the downloads section).

Submitting a sequence

You can submit your sequence in FASTA Format by pasting the sequence in the box below, or by uploading the file directly to the server.  A prediction will be returned to you.

Paste Single Sequence (FASTA format or raw sequence)

OR Select a file to upload (FASTA format, single sequence)

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Options

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The Proteus web server has been verified with Mozilla Firefox, Safari, Internet Explorer 5.5 and above, and Opera 7.6 and above.
If you submit a sequence with the "View results in web browser" option checked, and the page does not refresh and show progress, your browser is likely not supported (it must support XMLHttpRequest). If this is the case, please re-submit using the "email me when results are done" option.

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Proteus last updated July 11, 2006 		This page has been viewed times since 20/10/2008.
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